Several cases of transient leukopenia have been reported in patients receiving silver sulfadiazine therapy. The use of SILVADENE Cream 1% (silver sulfadiazine) in some cases of glucose-6-phosphate dehydrogenase-deficient individuals may be hazardous, as hemolysis may occur. However, the incidence of clinically reported fungal superinfection is low. If allergic reactions attributable to treatment with silver sulfadiazine occur, continuation of therapy must be weighed against the potential hazards of the particular allergic reaction.įungal proliferation in and below the eschar may occur. There is potential cross-sensitivity between silver sulfadiazine and other sulfonamides. Some of the reactions, which have been associated with sulfonamides, are as follows: blood dyscrasias including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, and hemolytic anemia dermatologic and allergic reactions, including life-threatening cutaneous reactions gastrointestinal reactions hepatitis and hepatocellular necrosis CNS reactions and toxic nephrosis. Although few have been reported, it is possible that any adverse reaction associated with sulfonamides may occur. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.Ībsorption of silver sulfadiazine varies depending upon the percent of body surface area and the extent of the tissue damage. Results of In Vitro Testing with SILVADENE ® Cream 1% (silver sulfadiazine) Concentration of Silver Sulfadiazine Number of Sensitive Strains/Total Number of Strains Tested Genus & Species Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Sufficient data have been obtained to demonstrate that silver sulfadiazine will inhibit bacteria that are resistant to other antimicrobial agents and that the compound is superior to sulfadiazine. Results from in vitro testing are listed below. It is bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast. The information you provide will only be used by Pfizer and parties acting on its behalf to send you materials and other helpful information and updates on Pfizer Hospital US, as well as related treatments, products, offers, and services.Silver sulfadiazine has broad antimicrobial activity. Pfizer understands your personal and health information is private. You agree to Pfizer’s Privacy Policy, available at which is hereby incorporated as part of these terms. You can also call customer service at 1-84. To request more information or to obtain help, text HELP to 292-89. text message program(s) to which you separately opted in. Doing so will only opt you out of the Pfizer Hospital US Website Texting program you will remain opted in to any other Pfizer Inc. To stop receiving text messages, text STOP to 292-89 or contact us at 1-84. Standard data rates may apply for SMS messages sent to your mobile phone.īy opting into the Pfizer Hospital US Website Texting program, you consent to receive up to 30 text messages per month from Pfizer Inc. By providing your email address and/or phone number, you are agreeing to receive transactional, product, supply information communications from Pfizer Inc.
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